The course aims to provide the student with theoretical and practical knowledge to optimize the design and management of logistics networks. For each of the topics covered, we focus on the quantitative analysis and modeling of the logistics problems encountered as well as on the identification of suitable solution techniques for the problems. Teaching will be in the form of lectures including discussions of articles, problem solving and utilizations of decision support tools. The primary pedagogical approach consists of describing the basic concepts, defining optimization problems, guiding students to develop an intuitive approach to solving small-scale problems, presenting models, algorithms and solution techniques/tools and, ultimately, enabling students to independently solve real-world business problems by utilizing computerized tools.